Jaundice in Dogs: Symptoms, Causes, Diagnosis, and Liver Support with LiverRX

What Is Jaundice in Dogs?

Jaundice — or icterus — is the yellow discoloration of a dog’s eyes, gums, inner ears, or skin. It occurs when bilirubin, a yellow pigment produced during red blood cell breakdown, accumulates in the bloodstream.

Normally, the liver filters bilirubin and excretes it through bile. When the liver is inflamed, the bile ducts are obstructed, or red blood cells are destroyed too quickly, bilirubin rises and causes jaundice.

Key point:Jaundice itself is not a disease — it is a clinical sign of underlying liver, gallbladder, bile duct, or blood disorders.

Read also: Dog Liver Anatomy, Prognosis, and End-of-Life Decisions (Full Guide)

Signs of Jaundice in Dogs

Jaundice can be seen in several areas:

• Whites of the eyes (sclera)

• Gums

• Ear flaps

• Belly, groin, and thin-furred areas

• Paw pads

• Skin (more visible on light-colored dogs)

Other symptoms often seen alongside jaundice:

• Loss of appetite

• Vomiting or diarrhea

• Lethargy or decreased energy

• Increased drinking or urination

• Abdominal pain or bloating

• Fever (common in infections such as leptospirosis)

• Weight loss

• Orange or dark urine

Emergency Red Flags — Seek Veterinary Care Immediately

• Rapidly worsening yellow discoloration

• Persistent vomiting

• Weakness or collapse

• Swollen or painful abdomen

• History of toxin exposure

• Yellow/orange urine

Jaundice in dogs almost always indicates moderate to severe systemic disease.

Read also: What to Feed a Dog With Jaundice: A Complete Nutritional Guide

Causes of Jaundice in Dogs

Jaundice has three main categories of causes:

1. Pre-Hepatic Causes (Before the Liver)

These occur when red blood cells are destroyed too quickly, creating excess bilirubin.

Common causes:

• Immune-mediated hemolytic anemia (IMHA)

• Blood parasites

• Onion or zinc toxicity

• Severe infections

• Genetic hemolytic disorders

IMHA is one of the most common and life-threatening causes in dogs.

2. Hepatic Causes (Inside the Liver)

These conditions impair the liver’s ability to process bilirubin.

Major hepatic causes in dogs:

• Chronic hepatitis

• Copper-associated hepatitis (seen in breeds like Labradors, Bedlington Terriers, Dalmatians)

• Leptospirosis

• Drug-induced liver injury

• Liver cancer or metastatic tumors

• Inflammation or fibrosis of liver tissue

When hepatocytes are damaged, bilirubin cannot be cleared efficiently.

3. Post-Hepatic Causes (After the Liver)

These involve bile duct obstruction, preventing bilirubin from exiting into the intestines.

Common causes:

• Gallbladder mucocele

• Pancreatitis

• Gallstones

• Inflammation around the bile duct

• Tumors compressing or blocking bile flow

• Biliary sludge

Obstructions cause bilirubin to back up into the bloodstream.

How Veterinarians Diagnose Jaundice in Dogs

Diagnosis focuses on identifying the root cause.

1. Physical Examination

Veterinarians evaluate:

• Gum and eye color

• Abdominal discomfort

• Hydration status

• Fever, lethargy, or jaundice severity

2. Laboratory Testing

• CBC: detects anemia, infection, and hemolysis

• Biochemistry panel: evaluates liver enzymes and bilirubin

• Urinalysis: checks for bilirubin in urine and kidney involvement

3. Advanced Diagnostics

• Abdominal ultrasound (extremely valuable for gallbladder mucoceles, blockages, liver texture)

• X-rays

• Leptospirosis testing

• Coombs test (for immune-mediated hemolysis)

• Fine-needle aspiration or biopsy of liver tissue

Timely diagnostics significantly improve the likelihood of recovery.

Treatment for Jaundice in Dogs

Treatment depends entirely on the underlying cause.

Medical Treatments

• IV fluids

• Antibiotics (for leptospirosis or bacterial cholangitis)

• Steroids (for chronic hepatitis or immune-mediated disease)

• Anti-nausea medication

• Pain control

• Vitamin K for clotting disorders

• Hospitalization for severe cases

Nutritional Support

• Prescription hepatic diets

• Low-copper diets for copper-associated disease

• Easily digestible, moderate-protein meals

Gallbladder and Bile Duct Management

• Medications to enhance bile flow

• Treatment for pancreatitis

• Emergency surgery if obstruction or mucocele rupture occurs

Long-term liver support improves outcomes and recovery speed.

Liver Support for Dogs with Jaundice: Why LiverRX Helps

LiverRX provides evidence-based liver support nutrients commonly used in veterinary liver protocols. It is designed to complement veterinary treatment and help the liver cope with inflammation, oxidative stress, and bile flow challenges.

LiverRx for Dogs

MYR 155.00

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LiverRX — Active Ingredients for Liver Support in Dogs

• S-adenosylmethionine (SAMe) — 225 mg

• Silybin A+B (Milk Thistle Extract) — 24 mg

• Vitamin E — 13 mg

• Vitamin C — 10 mg

How LiverRX Supports Dogs During Liver Recovery

✔ Increases Glutathione Levels

SAMe helps restore glutathione — the liver’s key antioxidant — improving detoxification and reducing bilirubin.

✔ Supports Bile Flow and Gallbladder Health

Silybin enhances bile movement and may benefit dogs prone to gallbladder mucoceles or cholestasis.

✔ Protects Liver Cells from Damage

Silybin stabilizes hepatocyte membranes and assists regeneration.

✔ Reduces Oxidative Stress

Vitamin E and C work together to protect the liver from inflammation-related damage.

✔ Useful for Dogs Recovering From:

• Leptospirosis

• Chronic hepatitis

• Gallbladder mucocele

• Copper-associated hepatitis

• Drug-induced liver injury

• Bile duct obstruction

• Pancreatitis-associated cholestasis

LiverRX is a supportive nutraceutical, not a replacement for veterinary treatment.

Read also: Best Liver Support Supplement for Dogs with Liver Disease: What to Know in 2025

Frequently Asked Questions (FAQ)

1. Is jaundice in dogs an emergency?

Yes. It indicates significant liver or bile duct dysfunction and requires urgent care.

2. Can jaundice in dogs be treated successfully?

Many dogs recover if the underlying cause is diagnosed early and treated appropriately.

3. What is the most common cause of jaundice in dogs?

Chronic hepatitis, leptospirosis, IMHA, and gallbladder mucocele are leading causes.

4. Is Milk Thistle safe for dogs?

Yes, when used in veterinary-formulated, standardized Silybin supplements.

5. How quickly does jaundice improve?

Depending on the cause, improvement may take several days to weeks.

6. Should supplements be used without veterinary advice?

No. Jaundice always requires a veterinary examination first.

Conclusion

Jaundice in dogs is a serious medical symptom that requires prompt veterinary evaluation. Many causes are treatable, and supportive liver care plays a key role in the recovery process.

LiverRX provides targeted liver support nutrients to help:

• Reduce oxidative stress

• Support bile flow

• Promote healthier liver function

• Help normalize bilirubin levels

• Protect liver cells during inflammation or disease

👉 Learn more about LiverRX for Dogs at rxsciences.co